HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[tert-butoxycarbonyl]-L-serine → (R)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[tert-butoxycarbonyl]-L-serine | HCID 98766 | — |
| Reactant | (R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid | HCID 637603 | — |
| Reactant | (S)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride | HCID 18599716 | — |
| Product | (R)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride | HCID 69195062 | — |
Reaction Steps
(R)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt was prepared from N-t-butyloxycarbonyl-D-serine by the procedures described in Itoh, et al., Chem. Pharm. Bull. 1986, 34, 1128-1147 for the preparation of (S)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt from N-t-butyloxycarbonyl-L-serine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425550B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-6e218ee8606c409ebe141bed79bde1d9 |
| Source note | uspto-grants-2008_09 |