HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,3R)-3-t-butyloxycarbonylamino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one → HCID 69196397, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,3R)-3-t-butyloxycarbonylamino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one | HCID 22871679 | — |
| Reactant | HCID 69195195 | HCID 69195195 | — |
| Product | HCID 69196397 | HCID 69196397 | — |
Reaction Steps
(2S,3R)-3-amino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one trifluoroacetate salt was prepared from (2S,3R)-3-t-butyloxycarbonylamino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one (Robi, et al., Bioorg. & Med. Chem. Lett. 1994, 4, 1789-1794) by treatment with a solution of trifluoroacetic acid-dichloromethane-tetrahydrofuran (1:10:10) at room temperature, followed by solvent evaporation and coevaporation with tetrahydrofuran under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425550B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-0fbc3c8b268b47f7879315692d9ae934 |
| Source note | uspto-grants-2008_09 |