4-(tert-Butyldimethylsilyloxy)cyclohexanone → N-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

HRID 311394Notes

Reaction equation

HRID 311394 reaction equation
[C:23]([CH3:24])([CH3:25])([CH3:26])[Si:27]([O:28][CH:29]1[CH2:30][CH2:31][C:32](=[O:35])[CH2:33][CH2:34]1)([CH3:36])[CH3:37].[NH:1]1[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][o:11][c:12]3[c:13]2[cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)=[O:22])[CH2:4]1>>[N:1]1([CH:32]2[CH2:31][CH2:30][CH:29]([O:28][Si:27]([C:23]([CH3:24])([CH3:25])[CH3:26])([CH3:36])[CH3:37])[CH2:34][CH2:33]2)[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][o:11][c:12]3[c:13]2[cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)=[O:22])[CH2:4]1

Participants

3

Reactant 2

HCID 106094304-(tert-Butyldimethylsilyloxy)cyclohexanoneHCID 58548680N-azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

Product 1

HCID 58548829N-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

Sources & evidence

ORD record
ord-e00a5965ecee4623aafd7c1157f31254
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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