Ammonia → HCID 22066028, compound

HRID 31148Notes

Reaction equation

HRID 31148 reaction equation
I[CH:2]1[C:12](=[O:13])[NH:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][NH:5][C:4]=2[CH2:3]1.[NH3:14]>>[NH2:14][CH:2]1[C:12](=[O:13])[NH:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][NH:5][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22066021HCID 22066021, compound

Product 1

HCID 22066028HCID 22066028, compound

Procedure

Thus obtained 3-iodo-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepin-2-one (109 mg) was dissolved in 7 M methanolic ammonia solution (5 mL) at room temperature under argon. When the starting material was consumed, the mixture was evaporated under vacuum, and the residue was purified by silica gel chromatography to obtain 3-amino-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepin-2-one.

Workup

  1. customWhen the starting material was consumed
  2. customthe mixture was evaporated under vacuum
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-888272a181f1400899274b87a24a2266
Source dataset
uspto-grants-2008_09
Patent number
US07425550B2

Reaction notes

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