2-(2,5-Difluorophenyl)-6-hydroxychroman-4-one → 2-(2,5-Difluorophenyl)chroman-4,6-diol

Participants

Role	Name	HCID	Charge
Reactant	2-(2,5-Difluorophenyl)-6-hydroxychroman-4-one	HCID 17978591	—
Reactant	2-Phenylchroman-4,6-diol	HCID 17978631	—
Product	2-(2,5-Difluorophenyl)chroman-4,6-diol	HCID 17978594	—

Reaction Steps

2-(2,5-Difluorophenyl)chroman-4,6-diol was prepared as described for 2-phenylchroman-4,6-diol in Example 8(a) starting from 1.0 g of 2-(2,5-difluorophenyl)-6-hydroxychroman-4-one. 1H NMR (400 MHz, d6-DMSO) δ: 8.87 (s, 1H), 7.39-7.22 (m, 3H), 6.89 (d, 1H, J 2.8 Hz), 6.63 (d, 1H, J 8.7 Hz), 6.56 (dd, 1H, J 8.7, 2.8 Hz), 5.50 (d, 1H, J 6.8 Hz), 5.35 (d, 1H, J 11.2 Hz), 4.89 (m, 1H), 2.28 (m, 1H), 1.95 (m, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07425568B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-2ec59b0dab0447d49ceea4b84320a6cf
Source note	uspto-grants-2008_09