2-(3-Fluorophenyl)chroman-6-ol → 2-(4-Ethylphenyl)chroman-6-ol

Participants

Reaction Steps

2-(4-Ethylphenyl)chroman-6-ol was prepared as described for 2-(3-fluorophenyl)chroman-6-ol in Example 9(c) starting from 425 mg of 2-(4-ethyl-phenyl)chroman-4,6-diol. The product was purified using heptane-ethyl acetate (3:1) as an eluant. 1H NMR (400 MHz, CD3OD) δ: 7.26 (d, 2H, J 8.2 Hz), 7.13 (d, 2H, J 8.2 Hz), 6.65 (d, 1H, J 8.6 Hz), 6.55 (dd, 1H, J 8.6, 2.8 Hz), 6.51 (d, 1H, J 2.8 Hz), 4.83 (dd, 1H, J 10.1, 2.3 Hz), 2.84 (m, 1H), 2.62 (m, 1H), 2.59 (q, 2H, J 7.6 Hz), 2.03 (m, 1H), 1.93 (m, 1H), 1.19 (t, 3H, J 7.6 Hz).

Provenance & Evidence