HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Fluorophenyl)chroman-6-ol → 2-(2-Fluorophenyl)chroman-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Fluorophenyl)chroman-6-ol | HCID 17978471 | — |
| Reactant | 2-(2-Fluorophenyl)chroman-4,6-diol | HCID 17978553 | — |
| Product | 2-(2-Fluorophenyl)chroman-6-ol | HCID 17978459 | — |
Reaction Steps
2-(2-Fluorophenyl)chroman-6-ol was prepared as described for 2-(3-fluorophenyl)chroman-6-ol in Example 9(c) starting from 800 mg of 2-(2-fluorophenyl)chroman-4,6diol. 1H NMR (300 MHz, d6-DMSO) δ: 7.50 (m, 1H), 7.39 (m, 1H), 7.26-7.19 (m, 2H), 6.63 (m, 1H), 6.53-6.50 (m, 2H), 5.21 (dd, 1H, J, 10.2, 2.3 Hz), 2.98 (ddd, 1H, J −16.9, 11.2, 6.0 Hz), 2.66 (ddd, 1H, J −16.9, 5.0, 2.9 Hz), 2.11 (m, 1H), 1.99 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425568B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-60e0c42d9c644cdea037bceae64794e6 |
| Source note | uspto-grants-2008_09 |