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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31247Generated: October 29, 2026

3-Amino-5-(trifluoromethyl)-2-(2-phenylchroman-6-yloxy)-aniline → 2-(2-Phenylindan-5-yloxy)-5-trifluoromethylbenzene-1,3-diamine

https://huagongshe.com/reaction/31247

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Amino-5-(trifluoromethyl)-2-(2-phenylchroman-6-yloxy)-anilineHCID 17978479—
Reactant5-(2,6-Dinitro-4-trifluoromethylphenoxy)-2-phenylindanHCID 17978523—
Product2-(2-Phenylindan-5-yloxy)-5-trifluoromethylbenzene-1,3-diamineHCID 17978506—

Reaction Steps

2-(2-Phenylindan-5-yloxy)-5-trifluoromethylbenzene-1,3-diamine was prepared as described for 2-(2-phenylchroman-6-yloxy)-5-trifluoromethylbenzene-1,3-diamine in Example 35(b) using 230 mg of 5-(2,6-dinitro-4-trifluoromethylphenoxy)-2-phenylindan. 1H-NMR (300 MHz, d6-DMSO): 7.33-7.27 (m, 4H), 7.22-7.18 (m, 1H), 7.14 (d, 1H, J 8.1 Hz), 6.73-6.69 (m, 2H), 6.31 (s, 2H), 4.98 (s, 4H), 3.64 (k, 1H, J 8.5 Hz), 3.26-3.18 (m, 2H), 2.96-2.86 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425568B2
Source datasetuspto-grants-2008_09
ORD IDord-b682c2f264c24d7eaf0c8d305c8529ae
Source noteuspto-grants-2008_09