5-Amino-2-(2-phenylchroman-6-yloxy)pyridine → 6-[2-(2,5-Difluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine

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Reaction Steps

6-[2-(2,5-Difluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine was prepared as described for 5-amino-2-(2-phenylchroman-6-yloxy)pyridine in Example 26 starting from 830 mg of 2-[2-(2,5-Difluorophenyl)chroman-6-yloxy]-5-nitropyridine (Example 14(d)). 1H NMR (300 MHz, d6-DMSO) δ: 7.51 (d, 1H, J 2.9 Hz), 7.36-7.25 (m, 3H), 7.05 (dd, 1H, J 8.6, 2.9 Hz), 6.84-6.68 (m, 4H), 5.29 (d, 1H, J 8.6), 4.99 (s, 2H), 2.96 (m, 1H), 2.72 (m, 1H), 2.14 (m, 1H), 2.01 (m, 1H).

Provenance & Evidence