N-[6-(2-phenylchroman-6-yloxy)pyridin-3-yl]methanesulfonamide → N-{6-[2-(2-Fluorophenyl)chroman-6-yloxy]pyridin-3-yl}methanesulfonamide

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N-{6-[2-(2-Fluorophenyl)chroman-6-yloxy]pyridin-3-yl}methanesulfonamide was prepared as described for N-[6-(2-phenylchroman-6-yloxy)pyridin-3-yl]methane sulfonamide in Example 46 starting from 400 mg of 6-[2-(2-fluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine (Example 51). The product was crystallised from a mixture of methanol and diethyl ether. 1H NMR (400 MHz, d6-DMSO) δ: 9.67 (s, 1H), 7.99 (d, 1H, J 2.8 Hz), 7.67 (dd, 1H, J 8.8, 2.8 Hz), 7.55 (m, 1H), 7.42 (m, 1H), 7.29-7.23 (m, 2H), 6.98 (dd, 1H, J 8.8 Hz), 6.92-6.84 (m, 3H), 5.35 (dd, 1H, J 10.4, 2.3 Hz), 3.01 (m, 1H), 2.99 (s, 3H), 2.76 (m, 1H), 2.16 (m, 1H), 2.04 (m, 1H).

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