6-(2-Azidoethoxy)-2-phenylchroman-4-one → HCID 17978599, compound

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Reaction Steps

6-(2-Aminoethoxy)-2-phenylchroman-4-one methane sulfonate was prepared as described for 2-(2-phenylchroman-6-yloxy)ethylamine methane sulfonate in Example 4 (b) starting from 6-(2-azidoethoxy)-2-phenylchroman-4-one. 1H NMR (400 MHz, d6-DMSO) δ: 7.91 (bs, 3H), 7.55-7.54 (m, 2H), 7.46-7.37 (m, 3H), 7.31 (d, 1H, J 3.1 Hz), 7.28 (dd, 1H, 8.8, 3.1 Hz), 7.12 (d, 1H, 8.8 Hz), 5.63 (dd, 1H, 13.0, 3.0 Hz), 4.17 (t, 2H, J 5.1 Hz), 3.25 (dd, 1H, J −16.9, 13.0 Hz), 3.23 (m, 2H), 2.86 (dd, 1H, J −16.9, 3.0 Hz), 2.29 (s, 3H).

Provenance & Evidence