Water → 3-(5-Chloro-8-fluoroisoquinolin-3-yl)-pyridin-2-ylamine
Reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH3:21][C:22]1([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27][B:28]([c:29]2[c:30]([NH2:35])[n:31][cH:32][cH:33][cH:34]2)[O:36]1.[Cl:1][c:2]1[c:3]2[cH:4][c:5]([O:13][S:14]([C:15]([F:16])([F:17])[F:18])(=[O:19])=[O:20])[n:6][cH:7][c:8]2[c:9]([F:12])[cH:10][cH:11]1.[Cs+:41].[Cs+:42].[O:43]1[CH2:44][CH2:45][O:46][CH2:47][CH2:48]1.[OH2:49].[cH:50]1[cH:51][cH:52][c:53]([P:54]([Pd:55]([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)([P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[P:94]([c:95]2[cH:96][cH:97][cH:98][cH:99][cH:100]2)([c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)([c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)[c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)[cH:125][cH:126]1>>[Cl:1][c:2]1[c:3]2[cH:4][c:5](-[c:29]3[c:30]([NH2:35])[n:31][cH:32][cH:33][cH:34]3)[n:6][cH:7][c:8]2[c:9]([F:12])[cH:10][cH:11]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-884c8a4ba1a5493584c08b265c99a7cb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
Loading…