Orm-10103 → HCID 17978628, compound

Participants

Reaction Steps

2-(2,4-Difluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 520 mg of 2-(2,4-difluorophenyl)chroman-4,6-diol (Example 69(b)). The product was recrystallised from a mixture of 2-propanol and diethyl ether. 1H NMR (400 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.8 Hz), 8.61 (dd, 1H, J 9.1, 2.8 Hz), 7.66 (m, 1H), 7.32 (m, 1H), 7.26 (d, 1H, J 2.9 Hz), 7.23 (d, 1H, 9.1 Hz), 7.17 (m, 1H), 7.02 (dd, 1H, J 8.9, 2.9 Hz), 6.88 (d, 1H, J 8.9 Hz), 5.70 (bs, 1H), 5.52 (dd, 1H, J 11.9, 1.5 Hz), 5.00 (m, 1H), 2.31 (m, 1H), 2.09 (m, 1H).

Provenance & Evidence