1-[4-(2-Phenoxyethoxymethyl)phenoxy]-2,3-epoxypropane → 6-[4-[2-[3-(4-(2-Phenoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 312925Notes

Reaction equation

HRID 312925 reaction equation
[NH2:23][CH2:24][CH2:25][O:26][c:27]1[c:28]([Cl:40])[cH:29][c:30]([C:33]2=[N:38][NH:37][C:36](=[O:39])[CH2:35][CH2:34]2)[cH:31][cH:32]1.[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH2:8][CH2:9][O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([O:16][CH2:17][CH:18]2[CH2:19][O:20]2)[cH:21][cH:22]1>>[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH2:8][CH2:9][O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([O:16][CH2:17][CH:18]([CH2:19][NH:23][CH2:24][CH2:25][O:26][c:27]2[c:28]([Cl:40])[cH:29][c:30]([C:33]3=[N:38][NH:37][C:36](=[O:39])[CH2:35][CH2:34]3)[cH:31][cH:32]2)[OH:20])[cH:21][cH:22]1

Participants

3

Reactant 2

HCID 151078101-[4-(2-Phenoxyethoxymethyl)phenoxy]-2,3-epoxypropaneHCID 151078226-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 151078756-[4-[2-[3-(4-(2-Phenoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Sources & evidence

ORD record
ord-51680467361d44379cda58c169030e13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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