5-Amino-2-(2-phenylchroman-6-yloxy)pyridine → 6-[2-(4-Fluorophenyl)chroman-6-yloxy]pyridin-3-ylamine

Participants

Reaction Steps

6-[2-(4-Fluorophenyl)chroman-6-yloxy]pyridin-3-ylamine was prepared as described for 5-amino-2-(2-phenylchroman-6-yloxy)pyridine in Example 26 starting from 3.04 g of 2-[2-(4-fluorophenyl)chroman-6-yloxy]-5-nitropyridine (Example 75(d)). 1H NMR (400 MHz, d6-DMSO) δ: 7.52-7.47 (m, 3H), 7.24 (m, 2H), 7.05 (dd, 1H, J 8.6, 3.0 Hz), 6.84-6.68 (m, 4H), 5.09 (dd, 1H, J 10.2, 2.1 Hz), 5.00 (bs, 2H), 2.93 (m, 1H), 2.69 (m, 1H), 2.13 (m, 1H), 1.98 (m, 1H).

Provenance & Evidence