(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(4-fluoro-3-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

HRID 312971Notes

Reaction equation

HRID 312971 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]2([c:19]3[cH:20][c:21]([O:26][CH3:27])[c:22]([F:25])[cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1.[n:28]1[cH:29][n:30][cH:31][c:32]([B:34]([OH:35])[OH:36])[cH:33]1>>[c:2]1(-[c:32]2[cH:31][n:30][cH:29][n:28][cH:33]2)[cH:3][c:4]([C:8]2([c:19]3[cH:20][c:21]([O:26][CH3:27])[c:22]([F:25])[cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 585795211-(3-Bromophenyl)-4-fluoro-1-(4-fluoro-3-methoxyphenyl)-1H-isoindol-3-amine

Product 1

HCID 462030724-Fluoro-1-(4-fluoro-3-methoxyphenyl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine

Sources & evidence

ORD record
ord-923166ea7de64e4da71686d227bccff2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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