2-Bromo-N-tert-butyl-1,3-thiazole-5-carboxamide → N-tert-butyl-2-[3-[6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl]piperidin-1-yl]-1,3-thiazole-5-carboxamide
Reaction equation
[Br:25][c:26]1[s:27][c:28]([C:31](=[O:32])[NH:33][C:34]([CH3:35])([CH3:36])[CH3:37])[cH:29][n:30]1.[OH:1][C:2]([CH2:3][C:4]1([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[CH2:5][CH2:6][N:7]([CH:11]2[CH2:12][NH:13][CH2:14][CH2:15][CH2:16]2)[C:8](=[O:10])[O:9]1)([CH3:23])[CH3:24]>>[OH:1][C:2]([CH2:3][C:4]1([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[CH2:5][CH2:6][N:7]([CH:11]2[CH2:12][N:13]([c:26]3[s:27][c:28]([C:31](=[O:32])[NH:33][C:34]([CH3:35])([CH3:36])[CH3:37])[cH:29][n:30]3)[CH2:14][CH2:15][CH2:16]2)[C:8](=[O:10])[O:9]1)([CH3:23])[CH3:24]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-f0412543549145b688a9e4e0e5fdcd54
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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