Diethyl Ether → tert-Butyl 4-((1-(5-chloro-1H-indazol-7-yl)-2-fluoroethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

HRID 313086Notes

Reaction equation

HRID 313086 reaction equation
[CH3:45][CH2:46][CH2:47][CH2:48][N+:49]([CH2:50][CH2:51][CH2:52][CH3:53])([CH2:54][CH2:55][CH2:56][CH3:57])[CH2:58][CH2:59][CH2:60][CH3:61].[CH3:62][CH2:63][O:64][CH2:65][CH3:66].[Cl:1][c:2]1[cH:3][c:4]2[cH:5][n:6]([CH2:36][O:37][CH2:38][CH2:39][Si:40]([CH3:41])([CH3:42])[CH3:43])[n:7][c:8]2[c:9]([CH:11]([CH2:12][F:13])[O:14][CH2:15][C:16]2([c:29]3[cH:30][cH:31][c:32]([F:35])[cH:33][cH:34]3)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[cH:10]1.[F-:44]>>[Cl:1][c:2]1[cH:3][c:4]2[cH:5][n:6][nH:7][c:8]2[c:9]([CH:11]([CH2:12][F:13])[O:14][CH2:15][C:16]2([c:29]3[cH:30][cH:31][c:32]([F:35])[cH:33][cH:34]3)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[cH:10]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 57545990HCID 57545990, compound

Product 1

HCID 57546100tert-Butyl 4-((1-(5-chloro-1H-indazol-7-yl)-2-fluoroethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-5d562f02876846a2beb8a8b77f8cbde9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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