反应详情

温度

108 °C

1 g of levofloxacin crude was put in suspension in 1.5 ml of DMSO. The mixture was heated to 108° C. until complete dissolution of the material. Then H2O (7.5 ml) was added over 10 minutes and the mixture was cooled to RT. The precipitate was filtrated under vacuum, washed with 1 ml of a mixture DMSO:H2O 1:5 and dried at 60° C. in an air-flow oven to give 840 mg (84%) of purified levofloxacin hemihydrate.

1. temperaturethe mixture was cooled to RT
2. filtrationThe precipitate was filtrated under vacuum
3. washwashed with 1 ml of a mixture DMSO:H2O 1:5
4. customdried at 60° C. in an air-flow oven