Potassium Iodide → 2-(4-Iodophenyl)-5-pyrrolidin-1-ylmethyl-[1,3,4]oxadiazole

Participants

Reaction Conditions

Reaction Steps

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in pyrrolidine (2 ml) and stirred for 18 hours at 20° C. The amine was then removed in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).

Provenance & Evidence