Potassium Iodide → 4-[5-(4-Iodophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-morpholine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in morpholine (2 ml) and stirred for 18 hours at 20° C. The amine was then removed in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).

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