2-Chloro-4-(trifluoromethyl)pyrimidine → N-(4-cyano-1-methyl-piperidin-4-yl)-2-(4-trifluoromethyl-pyrimidin-2-ylamino)-3-cyclohexyl-propionamide
Reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1.[NH2:12][CH:13]([C:14](=[O:15])[NH:16][C:17]1([C:24]#[N:25])[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)[CH2:26][CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1>>[c:2]1([NH:12][CH:13]([C:14](=[O:15])[NH:16][C:17]2([C:24]#[N:25])[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]2)[CH2:26][CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[n:3][cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1Participants
3
Sources & evidence
- ORD record
- ord-4b79d541084b4b00b0f069014e703353
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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