2-(4-bromophenyl)-1H-imidazole → N-Cyclopropyl-4'-(1H-imidazol-2-yl)-6-methyl-[1,1'-biphenyl]-3-carboxamide

HRID 31437Notes

Reaction equation

HRID 31437 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[CH:13]1([NH:16][C:17](=[O:34])[C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[C:20](B3OC(C)(C)C(C)(C)O3)[CH:19]=2)[CH2:15][CH2:14]1>>[CH:13]1([NH:16][C:17]([C:18]2[CH:23]=[C:22]([C:2]3[CH:7]=[CH:6][C:5]([C:8]4[NH:9][CH:10]=[CH:11][N:12]=4)=[CH:4][CH:3]=3)[C:21]([CH3:24])=[CH:20][CH:19]=2)=[O:34])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 116942652-(4-bromophenyl)-1H-imidazoleHCID 21914577N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide2×

Product 1

HCID 10448526N-Cyclopropyl-4'-(1H-imidazol-2-yl)-6-methyl-[1,1'-biphenyl]-3-carboxamide

Procedure

Example 8 was prepared using 2-(4-bromophenyl)-1H-imidazole and N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)benzamide (Intermediate 17).

Workup

  1. customExample 8 was prepared

Sources & evidence

ORD record
ord-2bc36df81f074c3dbf61319a78bfb864
Source dataset
uspto-grants-2008_09
Patent number
US07425555B2

Reaction notes

Loading…