HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Bromophenyl)-1,3-thiazol-2-amine hydrobromide → N-[4'-(2-Amino-4-thiazolyl)-6-methyl-[1,1'-biphenyl]-3-yl]-2-(1-pyrrolidinyl)-4-pyridinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Bromophenyl)-1,3-thiazol-2-amine hydrobromide | HCID 2787880 | — |
| Reactant | N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-2-pyrrolidin-1-yl-isonicotinamide | HCID 11258289 | — |
| Product | N-[4'-(2-Amino-4-thiazolyl)-6-methyl-[1,1'-biphenyl]-3-yl]-2-(1-pyrrolidinyl)-4-pyridinecarboxamide | HCID 10072721 | — |
Reaction Steps
Example 9 was prepared using using 4-(4-bromophenyl)-2-thiazolamine monohydrobromide and N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]-2-(1-pyrrolidinyl)-4-pyridinecarboxamide (Intermediate 20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425555B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-222359a1bdb64415908fbb769c7d9500 |
| Source note | uspto-grants-2008_09 |