2-(7-amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethylacetamide → 2-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N,N-dimethyl-acetamide

HRID 314391Notes

Reaction equation

HRID 314391 reaction equation
[Cl:21][c:22]1[n:23][cH:24][c:25]([F:43])[c:26]([NH:28][c:29]2[c:30]([O:41][CH3:42])[cH:31][c:32]([N:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)[cH:33][cH:34]2)[n:27]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:17][c:18]1[O:19][CH3:20])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[N:14]([CH3:15])[CH3:16])[CH2:9][CH2:10]2>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:17][c:18]1[O:19][CH3:20])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[N:14]([CH3:15])[CH3:16])[CH2:9][CH2:10]2)[c:22]1[n:23][cH:24][c:25]([F:43])[c:26]([NH:28][c:29]2[c:30]([O:41][CH3:42])[cH:31][c:32]([N:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)[cH:33][cH:34]2)[n:27]1

Participants

3

Reactant 2

HCID 672635242-(7-amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethylacetamideHCID 86633934(2-Chloro-5-fluoro-pyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 668302392-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N,N-dimethyl-acetamide

Sources & evidence

ORD record
ord-975dd044eef34b8aa6b48bc7b95e974f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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