Formic Acid → 6-chloro-2-methyl-4-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

HRID 314513Notes

Reaction equation

[CH2:32]=[O:33].[CH:29]([OH:30])=[O:31].[Cl:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[cH:12][cH:13][c:14]([CH:17]3[CH2:18][N:19]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:20][CH2:21]3)[cH:15][n:16]2)[c:5](=[O:9])[n:6]([CH3:8])[n:7]1.[OH2:34]>>[Cl:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[cH:12][cH:13][c:14]([CH:17]3[CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[cH:15][n:16]2)[c:5](=[O:9])[n:6]([CH3:8])[n:7]1

Participants

Reactant 4

HCID 284Formic Acid

HCID 712Formaldehyde

HCID 962Water

HCID 66742790Tert-butyl 3-(6-(6-chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)pyrrolidine-1-carboxylate

Product 1

HCID 667419726-chloro-2-methyl-4-(5-(1-methylpyrrolidin-3-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

Sources & evidence

ORD record: ord-0e3a953756214c9c85d1101b073cddc7
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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