Toluene → 3-(4-Chloro-3-dimethoxymethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

HRID 314521Notes

Reaction equation

HRID 314521 reaction equation
[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[CH:1]([O:2][CH3:3])([O:4][CH3:5])[O:6][CH3:7].[Cl:8][c:9]1[c:10]([CH:28]=[O:29])[cH:11][c:12](-[n:15]2[c:16](=[O:27])[n:17]([CH3:26])[c:18]([C:22]([F:23])([F:24])[F:25])[cH:19][c:20]2=[O:21])[cH:13][cH:14]1>>[CH:1]([O:4][CH3:5])([O:6][CH3:7])[c:10]1[c:9]([Cl:8])[cH:14][cH:13][c:12](-[n:15]2[c:16](=[O:27])[n:17]([CH3:26])[c:18]([C:22]([F:23])([F:24])[F:25])[cH:19][c:20]2=[O:21])[cH:11]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 9005Trimethyl orthoformateHCID 212012252-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

Product 1

HCID 212012303-(4-Chloro-3-dimethoxymethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

Sources & evidence

ORD record
ord-8a6605ece22e49ba9969b2900dd8fb10
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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