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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31454Generated: October 27, 2026

5-(4-Iodophenyl)-3-methyl-1,2,4-oxadiazole → Thiophene-3-carboxylic acid[6-methyl-4'-(3-methyl-[1,2,4]oxadiazol-5-yl)-biphenyl-3-yl]-amide

https://huagongshe.com/reaction/31454

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Iodophenyl)-3-methyl-1,2,4-oxadiazoleHCID 19703116—
ReactantN-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-thiophenecarboxamideHCID 21914662—
SolventDimethylformamideHCID 6228—
ProductThiophene-3-carboxylic acid[6-methyl-4'-(3-methyl-[1,2,4]oxadiazol-5-yl)-biphenyl-3-yl]-amideHCID 58629799—

Reaction Steps

Example 26 was prepared using 5-(4-iodophenyl)-3-methyl-[1,2,4]oxadiazole (Intermediate 12) and N-[4-methyl-3-(4,4,5,5, -tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]thiophene-3-amide (Intermediate 27) using DMF as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-74844d4cc8794ec8a7b66fc1f774d14d
Source noteuspto-grants-2008_09