Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31455Generated: October 25, 2026

5-(4-Iodophenyl)-3-methyl-1,2,4-oxadiazole → 6-Methyl-4'(3-methyl-[1,2,4]oxadiazol-5-yl)biphenyl-3-carboxylic acid [1,3,4]thiadiazol-2-ylamide

https://huagongshe.com/reaction/31455

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Iodophenyl)-3-methyl-1,2,4-oxadiazoleHCID 19703116—
Reactant4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-([1,3,4]thiadiazol-2-yl)-benzamideHCID 58656532—
SolventDimethylformamideHCID 6228—
Product6-Methyl-4'(3-methyl-[1,2,4]oxadiazol-5-yl)biphenyl-3-carboxylic acid [1,3,4]thiadiazol-2-ylamideHCID 10249016—

Reaction Steps

Example 27 was prepared using 5-(4-iodophenyl)-3-methyl-[1,2,4]oxadiazole (Intermediate 12) and 4-methyl-3-(4,4,5,5, -tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-([1,3,4]thiadiazol-2-yl)-benzamide (Intermediate 23) using DMF as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-7cfa817061d94cf982197f31a48d9bbf
Source noteuspto-grants-2008_09