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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31456Generated: October 26, 2026

3-(4-Bromo-3-methylphenyl)-5-methyl-1,2,4-oxadiazole → 6,2'-Dimethyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-3-carboxylic acid cyclopropylamide

https://huagongshe.com/reaction/31456

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Bromo-3-methylphenyl)-5-methyl-1,2,4-oxadiazoleHCID 12121944—
ReactantN-cyclopropylmethyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamideHCID 21914588—
SolventDimethylformamideHCID 6228—
Product6,2'-Dimethyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-3-carboxylic acid cyclopropylamideHCID 58629788—

Reaction Steps

Example 29 was prepared using 3-(4-bromo-3-methylphenyl)-5-methyl-[1,2,4]oxadiazole and N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 17) using DMF as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-504fe188c0684d49955ecc23ea31cc2a
Source noteuspto-grants-2008_09