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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31458Generated: October 27, 2026

3-(4-Bromo-3-methylphenyl)-5-methyl-1,2,4-oxadiazole → Thiophene-3-carboxylic acid[6,2'-dimethyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)biphenyl-3-yl]-amide

https://huagongshe.com/reaction/31458

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Bromo-3-methylphenyl)-5-methyl-1,2,4-oxadiazoleHCID 12121944—
ReactantN-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-thiophenecarboxamideHCID 21914662—
SolventDimethylformamideHCID 6228—
ProductThiophene-3-carboxylic acid[6,2'-dimethyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)biphenyl-3-yl]-amideHCID 58629791—

Reaction Steps

Example 31 was prepared using 3-(4-bromo-3-methylphenyl)-5-methyl-[1,2,4]oxadiazole and N-[4methyl-3-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]thiophene-3-amide (Intermediate 27) using DMF as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-1c2efb6d7a204208a663c64b3d7d56a3
Source noteuspto-grants-2008_09