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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31463Generated: October 25, 2026

2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazole → 6-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid (3-morpholin-4yl-phenyl)-amide

https://huagongshe.com/reaction/31463

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazoleHCID 676569—
Reactant4-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamideHCID 59791521—
SolventIsopropanolHCID 3776—
Product6-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid (3-morpholin-4yl-phenyl)-amideHCID 10049619—

Reaction Steps

Example 36 was prepared using 2-(4-iodophenyl)-5-methyl-[1,3,4]oxadiazole (Intermediate 15) and 4-methyl-N-(3-morpholin-4-phenyl)-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 5) with propan-2-ol as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-a4b8d48e0080424d84f52a79d258df2c
Source noteuspto-grants-2008_09