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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31466Generated: October 25, 2026

2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazole → 6-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid cyclopropylamide

https://huagongshe.com/reaction/31466

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazoleHCID 676569—
ReactantN-cyclopropylmethyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamideHCID 21914588—
SolventIsopropanolHCID 3776—
Product6-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid cyclopropylamideHCID 10065415—

Reaction Steps

Example 39 was prepared using 2-(4-iodophenyl)-5-methyl-[1,3,4]oxadiazole (Intermediate 15) and N-cyclopropyl-4methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 17) with propan-2-ol as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-126989eda33d4d468e1a7b1870ec316f
Source noteuspto-grants-2008_09