反应详情

N-Cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide (Intermediate 40) (50 mg) in triethylorthopropionate (5 ml) was heated at 150° C. for 18 hours. The excess triethylorthopropionate was evaporated under vacuum and the residue purified by bond-elut (silica), eluting with an ethyl acetate/cyclohexane gradient. The solvent was evaporated from the product fractions under vacuum to give N-cyclopropyl-4′-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1′-biphenyl-3-carboxamide.

1. customThe excess triethylorthopropionate was evaporated under vacuum
2. customthe residue purified by bond-elut (silica)
3. washeluting with an ethyl acetate/cyclohexane gradient
4. customThe solvent was evaporated from the product fractions under vacuum