2-(Bromomethyl)tetrahydro-2H-pyran → 1'-[(2-Isopropyl-1,3-thiazol-4-yl)methyl]-2'-oxo-1',2'-dihydrospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indole]-7'-carbonitrile

HRID 314807Notes

Reaction equation

HRID 314807 reaction equation
[Br:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:18]1.[Cl:1][CH2:2][c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1.[O:19]=[C:20]1[NH:21][c:22]2[c:23]([C:40]#[N:41])[cH:24][cH:25][cH:26][c:27]2[C:28]12[CH2:29][O:30][c:31]1[c:32]2[cH:33][c:34]2[c:35]([cH:39]1)[O:36][CH2:37][O:38]2>>[CH2:2]([c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1)[N:21]1[C:20](=[O:19])[C:28]2([c:27]3[c:22]1[c:23]([C:40]#[N:41])[cH:24][cH:25][cH:26]3)[CH2:29][O:30][c:31]1[c:32]2[cH:33][c:34]2[c:35]([cH:39]1)[O:36][CH2:37][O:38]2

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 27631934-(Chloromethyl)-2-isopropyl-1,3-thiazoleHCID 593522642'-Oxo-1',2'-dihydrospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indole]-7'-carbonitrile

Product 1

HCID 593521631'-[(2-Isopropyl-1,3-thiazol-4-yl)methyl]-2'-oxo-1',2'-dihydrospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indole]-7'-carbonitrile

Sources & evidence

ORD record
ord-bf16a5c88b3543078c5f5312e17d8a47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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