反应详情

温度

95 °C

A mixture of 1,2-dihydro-4-phenyl-7-methyl-2-oxo-3-quinoline carboxylic acid ethyl ester (2.5 g, 8.1 mmol) and conc. sulfuric acid (20 ml) was stirred with heat at 95° C. for 10 hours. The reaction mixture was poured into ice water to obtain a crystal precipitated by filtration. The crystal obtained was washed with water and methanol in this sequence to give 1.5 g (yield 70.6 of the title compound.

1. customto obtain a crystal
2. customprecipitated by filtration
3. customThe crystal obtained
4. washwas washed with water and methanol in this sequence
5. customto give 1.5 g (