2-Chloro-3-(trifluoromethyl)pyridine → 2-[4-Chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl]-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dione

HRID 315190Notes

Reaction equation

HRID 315190 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([F:20])[c:5](-[n:9]2[c:10](=[O:19])[n:11]3[c:12]([cH:13][c:14]2=[O:15])[CH2:16][CH2:17][CH2:18]3)[cH:6][c:7]1[OH:8].[Cl:21][c:22]1[n:23][cH:24][cH:25][cH:26][c:27]1[C:28]([F:29])([F:30])[F:31].[Cl:32][c:33]1[c:34]([O:35][c:36]2[n:37][cH:38][cH:39][cH:40][n:41]2)[cH:42][c:43](-[n:44]2[c:45](=[O:46])[n:47]3[n:52]([c:53]2=[S:54])[CH2:51][CH2:50][CH2:49][CH2:48]3)[c:55]([F:56])[cH:57]1>>[Cl:1][c:2]1[cH:3][c:4]([F:20])[c:5](-[n:9]2[c:10](=[O:19])[n:11]3[c:12]([cH:13][c:14]2=[O:15])[CH2:16][CH2:17][CH2:18]3)[cH:6][c:7]1[O:8][c:22]1[n:23][cH:24][cH:25][cH:26][c:27]1[C:28]([F:29])([F:30])[F:31]

Participants

4

Reactant 3

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 184029112-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dioneHCID 184029602-[4-chloro-2-fluoro-5-(2-pyrimidyloxy)phenyl]hexahydro-3-thioxo-1H-[1,2,4]triazolo[1,2-a]pyridazin-1-one

Product 1

HCID 184029542-[4-Chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl]-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dione

Sources & evidence

ORD record
ord-aea416ba891240f7bd7743a2d8dd881a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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