1-(3-Aminopropyl)-2-pyrrolidinone → 8-Indan-5-yl-5-oxo-2-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 315247Notes

Reaction equation

HRID 315247 reaction equation
[CH2:11]([CH3:12])[O:13][C:14](=[O:15])[c:16]1[c:17](=[O:39])[c:18]2[c:19]([n:20][c:21]([S:24]([CH3:25])(=[O:26])=[O:27])[n:22][cH:23]2)[n:28](-[c:30]2[cH:31][c:32]3[c:36]([cH:37][cH:38]2)[CH2:35][CH2:34][CH2:33]3)[cH:29]1.[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6](=[O:10])[CH2:7][CH2:8][CH2:9]1>>[NH:1]([CH2:2][CH2:3][CH2:4][N:5]1[C:6](=[O:10])[CH2:7][CH2:8][CH2:9]1)[c:21]1[n:20][c:19]2[c:18]([c:17](=[O:39])[c:16]([C:14]([O:13][CH2:11][CH3:12])=[O:15])[cH:29][n:28]2-[c:30]2[cH:31][c:32]3[c:36]([cH:37][cH:38]2)[CH2:35][CH2:34][CH2:33]3)[cH:23][n:22]1

Participants

3

Reactant 2

HCID 821111-(3-Aminopropyl)-2-pyrrolidinoneHCID 252229828-Indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Product 1

HCID 685838038-Indan-5-yl-5-oxo-2-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-4f8391c29221428c8260c5a6f697189f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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