HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-tert-Butoxycarbonylmethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester → 5-Amino-2-tert-butoxycarbonylmethyl-2H-pyrazole-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-tert-Butoxycarbonylmethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester | HCID 58646673 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-2-tert-butoxycarbonylmethyl-2H-pyrazole-3-carboxylic acid methyl ester | HCID 58646691 | 97.6% |
Reaction Steps
A solution of 2-tert-Butoxycarbonylmethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (3 gm) in ethyl acetate (60 ml) and acetic acid (4.5 ml) was hydrogenated at 50 psi hydrogen in the presence of 1.5 gm of 10% palladium/carbon for 3 hours. The mixture was then filtered and evaporated to obtain 2.62 gm of pure title product. ESI M+1=256.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425640B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-1e3b61653ac54a748a523ec6ae0b2891 |
| Source note | uspto-grants-2008_09 |