3-Bromo-4-chlorobenzoic acid → 3-bromo-4-chloro-N-{(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-N-methyl-benzamide

HRID 315444Notes

Reaction equation

HRID 315444 reaction equation
[Br:30][c:31]1[cH:32][c:33]([C:34](=[O:35])[OH:36])[cH:37][cH:38][c:39]1[Cl:40].[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][N:11]([C:16](=[O:17])[CH:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:25])[C:26]4([CH3:29])[CH2:27][CH2:28]4)[CH2:22][CH2:23]3)[CH2:12][CH:13]2[NH:14][CH3:15])[cH:5][cH:6][c:7]1[Cl:8]>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][N:11]([C:16](=[O:17])[CH:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:25])[C:26]4([CH3:29])[CH2:27][CH2:28]4)[CH2:22][CH2:23]3)[CH2:12][CH:13]2[N:14]([CH3:15])[C:34]([c:33]2[cH:32][c:31]([Br:30])[c:39]([Cl:40])[cH:38][cH:37]2)=[O:36])[cH:5][cH:6][c:7]1[Cl:8]

Participants

3

Reactant 2

HCID 27355443-Bromo-4-chlorobenzoic acidHCID 67025815[(3SR,4RS)-3-(3,4-Dichloro-phenyl)-4-methylamino-pyrrolidin-1-yl]-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yl]-methanone

Product 1

HCID 670256993-bromo-4-chloro-N-{(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-N-methyl-benzamide

Sources & evidence

ORD record
ord-f93ea65996c844919f2139658518d0fd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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