HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 59792850, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl (2r)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-{(1e)-3-[2-(4-methylbenzoyl)-1h-pyrrol-1-yl]prop-1-en-1-yl}benzyl)oxy]propionate | HCID 59792879 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59792850 | HCID 59792850 | — |
Reaction Steps
The compound of Example 68-4 (260 mg, 0.48 mmol) was dissolved in THF (5 ml), and thereto was added n-tetrabutylammonium fluoride (1 mol/liter in THF) (1.5 ml, 0.72 mmol) under ice-cooling. Under ice-cooling, the mixture was stirred for one hour, and thereto was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated saline, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425642B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-3c346d18f4f5487bbe9a2d98913b04a4 |
| Source note | uspto-grants-2008_09 |