Sodium ion → N-(5-(2-Amino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)methanesulfonamide

HRID 315590Notes

Reaction equation

HRID 315590 reaction equation
[Cl:30][c:31]1[c:32]([NH:56][S:57](=[O:58])(=[O:59])[CH3:60])[cH:33][c:34](-[c:37]2[cH:38][cH:39][c:40]3[n:41]([n:42]2)[c:43](-[c:50]2[cH:51][cH:52][n:53][cH:54][cH:55]2)[c:44]([NH:46][C:47](=[O:48])[CH3:49])[n:45]3)[cH:35][n:36]1.[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7](-[c:8]3[cH:9][c:10]([NH:11][S:12]([CH3:13])(=[O:14])=[O:15])[c:16]([Cl:17])[n:18][cH:19]3)[n:20][n:21]2[c:22]1-[c:23]1[cH:24][cH:25][cH:26][c:27]([F:28])[cH:29]1.[Na+:62].[OH-:61]>>[Cl:30][c:31]1[c:32]([NH:56][S:57](=[O:58])(=[O:59])[CH3:60])[cH:33][c:34](-[c:37]2[cH:38][cH:39][c:40]3[n:41]([n:42]2)[c:43](-[c:50]2[cH:51][cH:52][n:53][cH:54][cH:55]2)[c:44]([NH2:46])[n:45]3)[cH:35][n:36]1

Participants

5

Reactant 4

HCID 923Sodium ionHCID 961HydroxideHCID 44125495N-(6-(6-Chloro-5-(methylsulfonamido)pyridin-3-yl)-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamideHCID 44125498N-(5-(2-Amino-3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)methanesulfonamide

Product 1

HCID 44125378N-(5-(2-Amino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)methanesulfonamide

Sources & evidence

ORD record
ord-55102b0e33b140ed9a5847e55caa3c5c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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