Dimethyl Sulfoxide → Tert-butyl 2-[6-[(2-methylphenyl)methylcarbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

HRID 315929Notes

Reaction equation

HRID 315929 reaction equation
[CH2:19]1[N:20]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:21][CH:22]2[CH:23]1[CH2:24][NH:25][CH2:26]2.[CH3:1][c:2]1[c:3]([CH2:4][NH:5][C:6](=[O:7])[c:8]2[n:9][c:10]([Cl:14])[cH:11][n:12][cH:13]2)[cH:15][cH:16][cH:17][cH:18]1.[CH3:40][S:41]([CH3:42])=[O:43].[Na+:34].[Na+:35].[O-:36][C:37](=[O:38])[O-:39]>>[CH3:1][c:2]1[c:3]([CH2:4][NH:5][C:6](=[O:7])[c:8]2[n:9][c:10]([N:25]3[CH2:24][CH:23]4[CH2:19][N:20]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:21][CH:22]4[CH2:26]3)[cH:11][n:12][cH:13]2)[cH:15][cH:16][cH:17][cH:18]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylateHCID 566479346-Chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide

Product 1

HCID 67265977Tert-butyl 2-[6-[(2-methylphenyl)methylcarbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-2f4a567b243149b49722f4663bfc71b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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