3,5-Bis-trifluoromethylphenylboronic acid → [4-[3,5-Bis(trifluoromethyl)phenyl]-2,6-dimethylphenyl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

HRID 316064Notes

Reaction equation

HRID 316064 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1.[F:25][C:26]([c:27]1[cH:28][c:29]([B:37]([OH:38])[OH:39])[cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[cH:32]1)([F:40])[F:41]>>[c:2]1(-[c:29]2[cH:28][c:27]([C:26]([F:25])([F:40])[F:41])[cH:32][c:31]([C:33]([F:34])([F:35])[F:36])[cH:30]2)[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1

Participants

3

Reactant 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acidHCID 66901578(4-Bromo-2,6-dimethylphenyl)-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

Product 1

HCID 76610485[4-[3,5-Bis(trifluoromethyl)phenyl]-2,6-dimethylphenyl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

Sources & evidence

ORD record
ord-ab8e7f7ffa1e4df0a68cde7101aaaafc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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