2-Fluoroaniline → Tert-butyl 4-[(2-fluorophenyl)amino]piperidine-1-carboxylate

HRID 316474Notes

Reaction equation

HRID 316474 reaction equation
[F:23][c:24]1[cH:25][c:26]([NH:27][CH:28]2[CH2:29][CH2:30][N:31]([C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[CH2:39][CH2:40]2)[cH:41][cH:42][cH:43]1.[NH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22].[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[CH:2]1([NH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[F:22])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 95842-FluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 23137591tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

Product 1

HCID 43652152Tert-butyl 4-[(2-fluorophenyl)amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ea318be4bb0043bbba78fd5eeddafdb3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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