2-(6-Methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethanol → 2-(((3-Methyl-4-(2-(6-methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31648Notes

Reaction equation

HRID 31648 reaction equation
[Na:1].COC1OCC(C[O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[CH3:31][C:32]1([CH2:40][CH2:41]O)[O:39][CH2:38][C:35]2([CH2:37][CH2:36]2)[CH2:34][O:33]1>>[Na:1].[CH3:30][C:13]1[C:14]([CH2:18][S:19]([C:21]2[NH:25][C:24]3[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=3[N:22]=2)=[O:20])=[N:15][CH:16]=[CH:17][C:12]=1[O:11][CH2:41][CH2:40][C:32]1([CH3:31])[O:33][CH2:34][C:35]2([CH2:37][CH2:36]2)[CH2:38][O:39]1

Participants

3

Reactant 2

HCID 597924952-(6-Methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667761912-(((3-Methyl-4-(2-(6-methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 5.5%

Procedure

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 2-(6-methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethanol obtained in the step (35a) to obtain the title compound (163 mg, total yield: 5.5%) as a light yellow solid.

Workup

  1. customobtained in the step (35a)

Sources & evidence

ORD record
ord-9d51c841253e49d8ac5dabd9631f54eb
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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