2-(2-(Methoxymethyl)-1,3-dioxan-2-yl)ethanol → 2-(((4-(2-(2-(Methoxymethyl)-1,3-dioxan-2-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31650Notes

Reaction equation

HRID 31650 reaction equation
[Na:1].COC1OCC([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[CH3:31][O:32][CH2:33][C:34]1([CH2:40]CO)[O:39][CH2:38][CH2:37][CH2:36][O:35]1>>[Na:1].[CH3:31][O:32][CH2:33][C:34]1([CH2:40][CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[O:39][CH2:38][CH2:37][CH2:36][O:35]1

Participants

3

Reactant 2

HCID 597925492-(2-(Methoxymethyl)-1,3-dioxan-2-yl)ethanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667758482-(((4-(2-(2-(Methoxymethyl)-1,3-dioxan-2-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 7%

Procedure

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 2-(2-(methoxymethyl)-1,3-dioxan-2-yl)ethanol obtained in the step (36a) to obtain the title compound (304 mg, total yield: 7.0%) as a light yellow solid.

Workup

  1. customobtained in the step (36a)

Sources & evidence

ORD record
ord-82e907bf2faa4e48a383069cb40ff38a
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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