1,1-Dihydroxypropan-2-one → (2-(Fluoromethyl)-1,3-dioxolan-2-yl)methanol

HRID 31668Notes

Reaction equation

HRID 31668 reaction equation
[F:1][CH2:2][C:3]1([CH2:9][OH:10])[O:8][CH2:7][CH2:6]C[O:4]1.OC(O)C(=O)C>C(O)CO>[F:1][CH2:2][C:3]1([CH2:9][OH:10])[O:4][CH2:6][CH2:7][O:8]1

Participants

4

Reactant 2

HCID 131809821,1-Dihydroxypropan-2-oneHCID 59792600(2-(Fluoromethyl)-1,3-dioxan-2-yl)methanol

Product 1

HCID 59792379(2-(Fluoromethyl)-1,3-dioxolan-2-yl)methanolYield 13.8%

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

The same procedure as in the steps (44a) to (44c) using dihydroxyacetone except that ethylene glycol was used instead of 1,3-propanediol used in Example 44 to obtain the title compound (543 mg, total yield: 13.8%).

Sources & evidence

ORD record
ord-f98455c64b9644ab80c79cf17a2f0845
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Reaction notes

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