HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Diethyl-1,3-dioxolane-4-methanol → 2-(((4-((2,2-Diethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Diethyl-1,3-dioxolane-4-methanol | HCID 21902 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 2-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776196 | — |
| Product | 2-(((4-((2,2-Diethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775640 | 14.3% |
Reaction Steps
The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using (2,2-diethyl-1,3-dioxolan-4-yl)methanol obtained in the step (65b) above to obtain the title compound (418 mg, total 14.3% yield) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425634B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-c4f9e9966dc740ad87c6126e9a627e98 |
| Source note | uspto-grants-2008_09 |