(1,4-Dioxaspiro(4.5)decan-2-yl)methanol → 2-(((4-((2s)-1,4-Dioxaspiro[4.5]dec-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Participants

Role	Name	HCID	Charge
Reactant	(1,4-Dioxaspiro(4.5)decan-2-yl)methanol	HCID 20128	—
Reactant	m-Chloroperbenzoic acid	HCID 70297	—
Reactant	2-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66776196	—
Product	2-(((4-((2s)-1,4-Dioxaspiro[4.5]dec-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66776577	16.8%

Reaction Steps

The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using (+)-1,4-dioxaspiro[4.5]decane-2-methanol to obtain the title compound (500 mg, total 16.8% yield) as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07425634B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-ee29ebc8d72241f6a1ef6e2c8152d012
Source note	uspto-grants-2008_09